LISBP (Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés)
LISBP (Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés)

Overview

The LISBP (Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés) is a mixed research unit: INSA, INRA and CNRS with multidisciplinary activities on education, research and technology transfer in biotechnology and processes. It is a leading biotechnology laboratory in France, certified  ISO 90001, which couples top quality teams in microbiology and protein engineering/biocatalysis with process engineering teams to enable a ‘gene to process’ approach.

The LISBP has longstanding and world renown in fermentation technology, biocatalysis and metabolic engineering (bacteria, yeasts and more recently microalgae) with a high level of transfer to industry, and an emerging reputation for systems biology, molecular evolution of enzymes, metagenomics screening, fermentation, separation and purification processes. More recently this overall expertise has evolved towards a more innovative approach involving a synthetic biology approach and a shift towards redesigning metabolic potential for ambitious… GeT-Biopuces:  is an integrated genomics core facility specialized in genomics and transcriptomics via microarrays and new generation sequencing (NGS). The platform is equipped with two array platforms: Affymetrix (GeneChip fluidic station 450, hybridization oven 640 and scanner 3000 7G with autoloader) and Agilent technology. In addition, a Qarray Mini spotter allowing to spot some oligonucleotides on glass slides to create your own microarray is available. The platform is equipped with an Ion S5 sequencer (Ion Torrent technology-ThermoFisher Scientific) and an Ion OneTouch 2 System performing template amplification and enrichment as part of the manual workflow for the Ion S5 system. The platform has a nanodrop 2000 to quantify nucleic acids and proteins as well as a bioanalyzer 2100 (Agilent) providing sizing, quantitation, and purity assessments for DNA and RNA.

MetaToul: State-of-the-art equipment in NMR (800 MHz & 500 MHz spectrometers) and mass spectrometry (LTQ-Orbitrap, Q Exactive +, QTOF Xevo,  Q…. GeT-Biopuces: Genomic and Transcriptomic core facility (http://get.genotoul.fr)

Regroups both the expertise and the technology necessary for the analysis of gene expression at the level of entire genomes of different biological systems, notably that of micro-organisms using microarrays (Affymetrix-Agilent technologies) or NGS. Development of innovative technology for future generation of chip-based analysis. Support a wide variety of genomics projects on eukaryotic and prokaryotic genomes, even the most unusual ones (de novo sequencing or resequencing projects). Data analysis: quality control, normalization (R software and Bioconductor package) leading to differentially expressed genes analysis or functional enhancement. Analysis of NGS data. We provide theoretical and technical training.

METATOUL: Metabolomics-fluxomics (http://www.metatoul.fr)

METATOUL provides expertise and state-of-the-art methodologies in metabolomics and fluxomics for the functional analysis of metabolic networks with…. Yes. service.