The SME Support Programme Implementation Plan (SPIP) is a document to be shared and used with and by potential SME applicants interested on the BioMan4R2 Open call and the referring available financial support opportunities. The SPIP corresponds to the approved Guidelines for applicants where the details of the whole application process within the Open Call of BioMan4R2 are explained. The document provides all details for the whole application process and the referring requirements for application, such as for example an overview about the BioMan4R2 partner consortium and referring regional project partners, specific requirements for application, details about different kinds of available financial support opportunities, details about the evaluation process, requirements for monitoring activities and payment modalities.